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Wednesday, June 8, 2022

Glympse to Present Two Posters Demonstrating Novel Protease Biosensor Diagnostic Platform Detection of Hepatocellular Carcinoma at EASL ILC 2022

 Analysis demonstrating highly accurate detection (AUC ≥ 0.94) of HCC vs. Healthy in two independently tested, diverse cohorts of patients 

 Analysis demonstrating highly accurate detection (AUC = 0.93) of HCC vs. non-HCC cirrhosis patients 

CAMBRIDGE, Mass, June 8, 2022 /PRNewswire/ -- Glympse, a biotechnology company developing revolutionary technology to diagnose and monitor disease, today announced that it will have two poster presentations demonstrating that its novel protease biosensor diagnostic platform can detect hepatocellular carcinoma (HCC) at the European Association for the Study of the Liver (EASL) International Liver Congress 2022 (ILC). The conference will be held from June 22-26 at ExCeL in London, United Kingdom.  

HCC is the fifth leading cancer globally, and non-invasive diagnostic options are needed to improve early diagnosis for better treatment outcomes. Glympse has developed a novel diagnostic platform technology that utilizes biosensors and machine learning to measure protease activity in plasma samples and will present two analyses demonstrating the platform’s ability to detect HCC. In poster #SAT564, Glympse will present results from a study of two independently tested, diverse cohorts of patients (n = 94) with known HCC vs. healthy controls, which determined Glympse’s platform was effective at detecting HCC (AUC ≥ 0.94). In the second poster (#FRI236), Glympse utilized the platform technology to differentiate between plasma samples with diagnosed HCC and without HCC but with cirrhosis (n = 43 and 26, respectively).  Results showed that the protease activity platform was effective at HCC detection (AUC = 0.93) and has potential future utility for early diagnosis, considering 72% of the HCC cases had early-stage tumors.  

“Our data demonstrate that the Glympse protease-based diagnostic platform is showing very promising data in the early detection of HCC,” said Tram Tran, M.D., Chief Medical Officer of Glympse. “With proper validation, this technology could be used in surveillance strategies for earlier, easier, and more accurate diagnosis of HCC.”  

“The Glympse diagnostic platform continues to demonstrate highly accurate predictive capabilities for disease detection,” said Caroline Loew, Ph.D., Chief Executive Officer of Glympse. “Following our presentation at AASLD, in which we were able to predict NASH vs. healthy patients with 97% accuracy, these data at the EASL conference showcase the platform’s ability to highly accurately detect HCC. We look forward to the continued validation of this platform, and of the measurement of protease activity, to accurately diagnose and monitor disease for patients in need.”

Title: Novel and accurate measurement of differential protease activity in diagnosed HCC patients compared to non-HCC cirrhotic patients    Presented By: Amit Singal, M.D.  

Poster Session: Non-invasive assessment of liver disease except NAFLD   Time/Date: June 24, 2022, 9:00 a.m. - 6:30 p.m. BST   

Abstract #: FRI236    

Title: Measurement of protease activity using novel plasma biosensors can accurately detect HCC  

Presented By: Tram Tran, M.D.  

Poster Session: Liver tumours: Clinical aspects except therapy  Time/Date: June 25, 2022, 9:00 a.m. - 6:30 p.m. BST  

Abstract #: SAT564


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